Should you take GLP-1s?

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained prominence in recent years for their role in managing type 2 diabetes and obesity. Medications like semaglutide (found in Ozempic and Wegovy) and tirzepatide (Mounjaro) are notable examples. You hear a lot about them online, but it's really important to understand what they actually do, so here you go. ​Nature

Mechanism of Action: How Do GLP-1 RAs Work?

GLP-1 RAs mimic the action of the endogenous hormone GLP-1. They bind to GLP-1 receptors, leading to several physiological responses:​Wikipedia

• Insulin Secretion: They stimulate the pancreas to release insulin in response to food intake, aiding in blood sugar regulation. ​Cleveland Clinic
  

• Glucagon Suppression: They inhibit glucagon release, a hormone that increases blood sugar levels. ​Nature
  

• Delayed Gastric Emptying: They slow down the movement of food from the stomach to the small intestine, promoting a feeling of fullness. ​Mayo Clinic
  

• Appetite Suppression: They act on the central nervous system to reduce appetite and food intake. ​BPS Journals
  

Long story short, they make you feel full. They basically turn off the receptor that tells your brain that you are hungry.

It's important to note that while GLP-1 RAs assist in weight loss by reducing appetite and caloric intake, they do not directly increase metabolism or burn fat.​

The Importance of Nutritional Awareness

With diminished appetite, there's a risk of inadequate nutrient intake, particularly protein. Insufficient protein can lead to muscle atrophy, underscoring the need for a balanced diet rich in essential nutrients.​

Potential Missteps in GLP-1 RA Usage

Common pitfalls include:

1. Overeating Despite Reduced Appetite: Ignoring satiety signals can lead to gastrointestinal discomfort.​

2. Under-Eating: Excessive calorie restriction may result in muscle loss and a gaunt appearance, sometimes referred to as "Ozempic face."​
   

Advancements: GLP-2 and GLP-3 Agonists

Emerging therapies, such as tirzepatide (a dual GLP-1 and GIP receptor agonist), have shown promise in enhancing appetite suppression with fewer gastrointestinal side effects. Additionally, preliminary studies suggest that GLP-1 RAs may reduce cravings for substances like alcohol and nicotine, indicating potential benefits beyond weight management. ​

Considerations Before Initiating GLP-1 RA Therapy

For individuals significantly overweight (e.g., 30 pounds or more), the health benefits of weight loss may outweigh potential side effects. However, it's essential to consult with a healthcare provider to determine the most appropriate treatment plan.​ Just make sure that they do prescribe these peptides, or you decide to self administer them, that you have an appropriate meal plan in place in order to take in the required amount of protein to combat muscle atrophy. In other words, you still have to eat, and you still have to eat protein so your body doesn't get hungry and eat itself. The peptides won't do that, it'll happen naturally because you're not eating. In order to get maximum effects, you also need to have a structured workout plan in place to build that protein into quality muscle so that you're strong going into your older age. It doesn't do anyone any good to wither away.

Crossing the Rubicon

Look at it this way, if you have to swim across a river is 300 yards wide, you can totally do it. It's not going to be easy. You could also do it wearing a life jacket. Sure you still have to cross the river and swim, but it's a lot easier of some support.

My take is that if you're more than 30 pounds overweight, as of right now I'm not aware of any downside to taking these to help assist in a weight loss program. I would suggest taking the highest quality peptides available - those that containers appetite or retatrutide. You can pay a lot of money at a clinic for these, or if you want to do a little research they are also available online, sold as research chemicals, technically " not for human consumption." If you catch the drift.

Conclusion

GLP-1 receptor agonists can be valuable tools in weight management when used correctly. They should complement, not replace, a comprehensive approach that includes proper nutrition and physical activity. Always seek medical advice before starting any new medication.​

Disclaimer: This article is for informational purposes only and does not constitute medical advice.